Skip to content

Kawasaki Disease and Multisystem Inflammatory Syndrome in Children: An Overview and Comparison

of Dr. John B. Darby, Dr.ssa Jennifer M. Jackson • September 2022
Kawasaki disease (KD) and multisystem inflammatory syndrome in children (MIS-C) are inflammatory conditions that present diagnostic and therapeutic challenges to the physician. Although many of their features overlap, they are two distinct conditions. KD is a febrile illness most commonly affecting children younger than five years. It manifests with prolonged fever and at least four of the following features: bilateral bulbar conjunctivitis, mucositis, diffuse maculopapular rash, extremity changes, and cervical lymphadenopathy of 1.5 cm or more in diameter. Patients with MIS-C may have many of the same manifestations but tend to have higher rates of gastrointestinal and neurocognitive symptoms and signs of shock on presentation. Both conditions are associated with cardiac sequelae, including coronary artery aneurysms, although children with MIS-C are at high risk of developing ventricular dysfunction and depressed cardiac output. Lymphocytopenia, thrombocytopenia, elevated troponin, and elevated B-type natriuretic peptide are key laboratory findings of MIS-C that can help distinguish it from KD. The use of intravenous immune globulin is well established in KD and also appears to have a role in the treatment of MIS-C. Aspirin has been used in KD for an anti-inflammatory effect, and low-dose aspirin is recommended for MIS-C to reduce the risk of thrombosis. In addition to supportive care, patients with MIS-C may benefit from immunomodulatory medications, although data on this topic are evolving.

(Am Fam Physician. 2021; 104(3): 244-252. Copyright © 2021 American Academy of Family Physicians.)

Related Articles

Dizziness: Evaluation and Management

Dizziness: Evaluation and Management

Dr. Tyler S. Rogers, Dr.ssa Mary Alice Noel, Dr. Benjamin Garcia
November 2023


Iscriviti per accedere ai contenuti digitali


Puoi accedere al sito di Minuti Digitale con le stesse credenziali dell’area riservata del sito di Fondazione Internazionale Menarini

non sei ancora registrato? premi QUI per iniziare

hai dimenticato la tua password? resetta la password

Ricerca Edizione

Search Edition:



You can access the Minuti Digitale website with the same credentials as those used for registering on the Fondazione Internazionale Menarini website

not registered? click here

forgot your password? reset your password



Puede acceder al sitio de Minuti Digitale con las mismas credenciales del área reservada del sitio de la Fondazione Internazionale Menarini

no estas registrado? premi QUI

Olvidaste tu contraseña? restablecer la contraseña

Reset Password

Inserisci il tuo indirizzo email per ottenere un link di reset password.


Effettuerai il reset sul sito di Fondazione Menarini e potrai successivamente effettuare il login su Minuti con le stesse credenziali.

Reset Password

Enter your email address to obtain a password resetting link.


After performing the resetting on the Fondazione Menarini website, you can then log in to Minuti with the same credentials.

Reset Password

Introduzca su dirección de correo electrónico para obtener el enlace para restablecer su contraseña.


Llevará a cabo el restablecimiento en el sitio de la Fondazione Menarini y luego podrá iniciar sesión en Minuti con las mismas credenciales.

error: Download disabled!